Proc Natl Acad Sci USA 1997; 94: 2041–2044. At a holding potential of –60 mV, 200 μM zinc increased by 361% the currents elicited by acetylcholine (ACh currents) for α4β4 and by 182% for α1β1γδ nAChRs. We more or less follow the paleo diet, but I have tried to research a bit on nutritional supplements that might be helpful. J Neurochem 1999; 73: 1043–1050. Prozac (fluoxetine) is an antidepressant and is classified as an SSRI (selective serotonin reuptake inhibitor). Zinc deficiency leads to decreased zinc in the nerve synapse, which results in an increase in the NMDA receptors. The authors seem to brush this off as of no importance, but I find it strange that this would be the only nutrient found to be low if dietary choices were to blame for the deficiency. I came across an abstract to a study (http://pediatrics.aappublications.org/content/79/2/218.short) in which male adolescent marijuana users were shown to have lower zinc levels. Thank you for visiting nature.com. Vizi ES, Lendvai B . García-Colunga J, González-Herrera M, Miledi R . The next day, each oocyte was injected with 0.5–50 ng of the cRNA mixture in a volume of 50 nl water. Prozac is approved for obsessive compulsive disorder (OCD), which can overlap with anxiety disorders. Nicotinic receptor subtypes and cognitive function. 12 mV), and all displayed the inward rectification characteristic of ACh current mediated by neuronal nAChRs,10, 18 such that at voltages more positive than zero the membrane current was near zero. Zinc is a trace element that has been long implicated in … In the meantime, to ensure continued support, we are displaying the site without styles 300 or more enzymes in our bodies use zinc as a buddy to help them do their thing, making DNA, protein synthesis, cell division, all hugely important stuff. Surprisingly, now zinc failed to cause the ACh current to increase, and after the three substances had been transiently co-applied the ACh current recovery was very slow. Additionally, zinc increased slightly the ACh current in the presence of fluoxetine on muscle α1β1γδ nAChRs (Figure 2b, c, d, c), while the ACh current elicited by neuronal receptors was not altered (Figure 1b, c). Since the body has no special zinc storage capability, its important to consume a bit of zinc on a regular basis (1). When the insults are chronic (unalleviated stress, gallons of inflammatory-promoting omega-6 fatty acids, weird glutens and lectins, chronic depression-causing viral infections such as herpes, HIV, or Epstein Barr), the whole system becomes dysregulated. Fluoxetine treatment also increased cell survival, particularly in wild type mice, though it did not affect proliferation. Blockage of muscle and neuronal nicotinic acetylcholine receptors by fluoxetine (Prozac). These receptors respond to glutamate, an excitatory neurotransmitter that can be responsible for toxic effects in the brain if there is too much. Thanks! Goodnick PJ . Their more detailed study may help understand the bases of the various forms of depression and of the unwanted side effects, all of which will lead to more rational treatments for these devastating diseases. PubMed Google Scholar. On the other hand, it is important to note that zinc has been linked to the psychopathology and treatment of depression.27, 28 Additionally, zinc content is not altered in the hippocampus, and the potency of zinc to inhibit N-methyl-D-aspartate receptors is reduced in suicidal victims.29 Thus, zinc appears to exert antidepressant-like effects probably by interacting with N-methyl-D-aspartate receptors and involving the L-arginine-nitric oxide pathway.30, 31. Zinc is also critical to cell signaling (a major receptor motif, the “zinc finger” is as famous as the G protein in cell biology circles). Nowak G, Schlegel-Zawadzka M . This work was supported by Grants from the Consejo Nacional de Ciencia y Tecnología, México 35033-N (to JGC), G25775N (to JGC and RM), a CONACYT scholarship (to EVG) and by a National Science Foundation (Neuronal and Glial Mechanisms) Grant 998285 (to RM). What should be up is down. Extra zinc might help. Picciotto MR, Brunzell DH, Caldarone BJ . Moreover, when ACh-activated nAChRs were exposed first to fluoxetine and then zinc was added, the potentiating effect of zinc was very small for muscle nAChRs and was nil for neuronal receptors. A new theory aims to make sense of it all ( I–V ) relationships for zinc and )... Body is found in our urine, sweat, and you get `` excitotoxicity. styles and JavaScript forced., Polenzani L, Miledi R and mutant neuronal α7 nicotinic receptors a biomarker depression! More than 50 mg a day can lead to improper copper metabolism, altered iron,. Lanthanum on different types of nicotinic acetylcholine receptors tried to research a bit nutritional... 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